Casas Grandes (Spanish for Great Houses; also known as Paquimé) is a prehistoric archaeological site in the northern Mexican state of Chihuahua. Construction of the site is attributed to the Mogollon culture. Casas Grandes has been designated a UNESCO World Heritage Site under the purview of INAH and a "Pueblo Mágico" since 2015.

Casas Grandes is one of the largest and most complex Mogollon culture sites in the region. Settlement began after 1130 AD, and the larger buildings developed into multi-storied dwellings after 1350 AD. The community was abandoned approximately in 1450 AD. Casas Grandes is regarded as one of the most significant Mogollon archaeological zones in the northwestern Mexico region, linking it to other sites in Arizona and New Mexico in the United States, and demonstrating the extent of the Mogollon sphere of influence.

The Casas Grandes complex is situated in a broad, fertile valley along the Casas Grandes or San Miguel River, approximately 56 kilometres (35 mi) south of Janos and 240 kilometres (150 mi) northwest of the state capital, Chihuahua. The settlement depended on irrigation to sustain its agricultural activities.

The archaeological zone is contained within the eponymous modern municipio (municipality) of Casas Grandes. The valley and region have been inhabited by aboriginal groups for millennia.