The Sanctuary of Imām 'Alī (Arabic: حَرَم ٱلْإِمَام عَلِيّ, romanized: Ḥaram al-ʾImām ʿAlī), also known as the Mosque of 'Alī (Arabic: مَسْجِد عَلِيّ, romanized: Masjid ʿAlī), located in Najaf, Iraq, is a mausoleum which Shia and Sunni Muslims believe contains the tomb of 'Alī ibn Abī Tālib, a cousin, son-in-law and companion of the Islamic Prophet Muhammad. The Shī'as consider 'Alī as their first Imām and the first of the twelve caliphs of Muhammad, and the Sunnis regard him as the fourth Sunni Rashid Caliph. According to Shī'ite belief, buried next to 'Alī within this mosque are the remains of Adam and Nuh (Noah). Each year, millions of pilgrims visit the Shrine and pay tribute to Imām 'Alī.

The shrine monument has been built and rebuilt numerous times throughout history; the current shrine dates back to the mid-Safavid period. Its construction began in 1621 under the orders of Shah Abbas the Great and was completed in 1631 after his death. Baha' al-din al-'Amili was appointed as the architect and the structure was designed in the classical Safavid Persian style. Over time the shrine has undergone various notable renovations aimed to enhance its beauty and grandeur, most notably the gilding of the dome and minarets of the shrine in 1743 by Nader Shah Afshar.