The Holmdel Horn Antenna is a large microwave horn antenna that was used as a satellite communication antenna and radio telescope during the 1960s at the Bell Telephone Laboratories facility located on Crawford Hill in Holmdel Township, New Jersey, United States. It was designated a National Historic Landmark in 1989 because of its association with the research work of two radio astronomers, Arno Penzias and Robert Wilson.

In 1965, while using this antenna, Penzias and Wilson discovered the cosmic microwave background radiation (CMBR) that permeates the universe. This was one of the most important discoveries in physical cosmology since Edwin Hubble demonstrated in the 1920s that the universe was expanding. It provided the evidence that confirmed George Gamow's and Georges Lemaître's "Big Bang" theory of the creation of the universe. This helped change the science of cosmology, the study of the universe's history, from a field for unlimited theoretical speculation into a discipline of direct observation. In 1978 Penzias and Wilson received the Nobel Prize for Physics for their discovery.