The Grand Staircase–Escalante National Monument (GSENM) is a United States national monument protecting the Grand Staircase, the Kaiparowits Plateau, and the Canyons of the Escalante (Escalante River) in southern Utah. It was established in 1996 by President Bill Clinton under the authority of the Antiquities Act with 1.7 million acres of land, later expanded to 1,880,461 acres (7,610 km²). In 2017, the monument's size was reduced by half in a succeeding presidential proclamation, and it was restored in 2021. The land is among the most remote in the country; it was the last to be mapped in the contiguous United States.

The monument is administered by the Bureau of Land Management (BLM) as part of the National Conservation Lands system. Grand Staircase–Escalante is the first and largest national monument managed by the BLM. Visitor centers are located in Cannonville, Big Water, Escalante, and Kanab.