The village dates from the 13th century or slightly earlier, but the area had previously been settled by the Romans.[1]

In 2016 and 2017 Central Italy seismic events hit Castelluccio hard, destroying roughly 60% of the town, forcing the evacuation of all inhabitants and the total closure of all road and/or offroad access. Certain roads were scheduled for partial reopening in July 2017. As of 2018, the village can be reached again, and temporary buildings have been erected housing bars and shops.