Agrigento (Italian: [aɡriˈdʒɛnto] ; Sicilian: Girgenti [dʒɪɾˈdʒɛndɪ] or Giurgenti [dʒʊɾˈdʒɛndɪ]) is a city on the southern coast of Sicily, Italy and capital of the province of Agrigento.

Founded around 582 BC by Greek colonists from Gela, Agrigento, then known as Akragas, was one of the leading cities during the golden age of Ancient Greece. The city flourished under Theron's leadership in the 5th century BC, marked by ambitious public works and the construction of renowned temples.

Despite periods of dormancy during the Punic Wars, Agrigento emerged as one of Sicily's largest cities in the Republican era. During the Principate, Agrigento's strategic port and diverse economic ventures, including sulfur mining, trade and agriculture, sustained its importance throughout the high and late Empire. Economic prosperity persisted in the 3rd to 4th centuries AD, but excavations show decline in activity after the 7th century.

Agrigento is also the place of birth to several notable personalities, among which it is worth to mention Empedocles (5th century BC), the Ancient Greek pre-Socratic philosopher, who was a citizen of ancient Akragas, and Luigi Pirandello (1867–1936), dramatist and Nobel prize winner for literature,who was born at contrada u Càvusu in Agrigento.

Agrigento, included among the UNESCO world heritage sites in 1997, was named Italian capital of culture for 2025.