The "Waters of Immortality" in Tskaltubo were probably known already in the 7th-9th centuries, when the oldest historical records are dated. Since the 18th century several foreign researchers gave word of the healing properties of these springs:Berlin Society of Friends of Natural Science (1782); J.Klaproth (1815); A. Jolenberg (1897). By 1920, after chemical analysis had revealed the uniqueness of the water, Tskaltubo was officially declared a medical spa resort and achieve the status of city in 1953.

In 1920 the territory of Tskaltubo became state property and it acquired the function of balneology resort. The building of the resort started in 1926. In 1931, a decree by the government of Georgian Soviet Republic designed Tskaltubo as a spa resort and balneology center.

In 1950-1951, architects I.Zaalishvili and V.Kedia prepared a project plan for the town where sanatoriums form a circle around a park, recreation and balneology facilities. Tskaltubo was divided into the following zones: balneological, sanitarian and living.

In 1953, Tskaltubo became the important spa-resort during the Soviet times. At different times, there were built 19 sanatoriums and pensions, nine baths, resort park, Branch of Scientific Institute of balneology and physiotherapy.

As one of Georgia's flagship historic spa towns, the town is still popular for the qualities of its waters. Tskaltubo mineral waters are famous for their stable physical and chemical composition and they are categorized as slight radon chloride –magnesium waters. The high-performance spa preventive effect of mineral waters is conditioned by their complex content and particular fusion of salt components. In Tskaltubo the bath taking has a peculiar technique, the treatment take place under the constant running water ( mineral water constantly flows in and out of the spa) and the water permanently preserves physical-chemical and mineral compositions. The water consists of six components and it penetrates into the human body via pores. Constituent ingredients in number are far below the permissible minimum, temperature of water is 33-35 C, it is very soft, pure and odorless.

Visitor numbers to Tsqaltubo dwindled after the dissolution of the Soviet Union, and currently the spa town only receives approximately 700 visitors a year. Since 1993 many of the sanatorium complexes have been devoted to housing some 9000 refugees, primarily women and children, displaced from their homes by the conflict in nearby Abkhazia.[1]

There have been a number of plans and projects to renovate and reconstitute Tskaltubo as a major resort.[1]