St. Mark's Coptic Orthodox Cathedral (Arabic: كاتدرائية القديس مرقس القبطية الأرثوذكسية) is a Coptic church located in the Abbassia District in Cairo, Egypt. The cathedral is the Seat of the Coptic Orthodox Pope. It was built during the time when Pope Cyril VI of Alexandria was Pope of the Coptic Orthodox Church, and was consecrated on 25 June 1968.

The church is dedicated to St. Mark the Evangelist, an apostle of Jesus and founder of the Coptic Orthodox Church. Relics of his life are kept inside. It was, until 2019, (after the inauguration of the new Nativity Cathedral) the largest cathedral in Africa and the Middle East.