The Peggy Guggenheim Collection is an art museum on the Grand Canal in the Dorsoduro sestiere of Venice, Italy. It is one of the most visited attractions in Venice. The collection is housed in the Palazzo Venier dei Leoni, an 18th-century palace, which was the home of the American heiress Peggy Guggenheim for three decades. She began displaying her private collection of modern artworks to the public seasonally in 1951. After her death in 1979, it passed to the Solomon R. Guggenheim Foundation, which opened the collection year-round from 1980.

The collection includes works of prominent Italian futurists and American modernists working in such genres as Cubism, Surrealism and abstract expressionism. It also includes sculptural works. In 2017, Karole Vail, a granddaughter of Peggy Guggenheim, was appointed Director of the collection, succeeding Philip Rylands, who led the museum for 37 years.