In 1954, Pisit and Nongnooch Tansacha purchased 1,500 rai of land on the garden's modern location. The couple had originally planned to use the land as a fruit location for several foreign and native fruits, including coconuts, mangoes, and oranges. However, Nongnooch decided to turn the land into a tropical garden after being inspiried by a trip abroad.[1]

The garden opened to the public in 1980, and in 1983 the garden's management was handed to Nongnooch's son, Kampon.[1]

From 1996 to 1997, Kampon expanded the garden's lakes and the soil dug up was placed in a valley which was initially used as a sunflower field. Eventually, Kampon decided to turn the area in the French Gardens based on the Gardens of Versailles, which opened in 1998.[2]

In 2016, the park began construction on Dinosaur Valley, which opened in 2017.[3]

On 17 May 2018, the ambassador of Bhutan to Thailand, Che Wang Choel Dorje, gifted the garden nine prayer flags of Bhutan in a Montra flag ceremony.[4]

In 2019, controversy ensued when a tourist uploaded images that suggested mistreatment of the elephants in their care, an accusation the Botanical Gardens has disputed.[citation needed]