San Antonio Missions National Historical Park is a National Historical Park and part of a UNESCO World Heritage Site preserving four of the five Spanish frontier missions in San Antonio, Texas, US. These outposts were established by Catholic religious orders to spread Christianity among the local natives. These missions formed part of a colonization system that stretched across the Spanish Southwest in the 17th, 18th, and 19th centuries.

In geographic order from north (upstream of the San Antonio River) to south (downstream) the missions are Mission Concepción, Mission San Jose, Mission San Juan, and Mission Espada. The Espada Aqueduct, also part of the Park, is due west of Mission San Juan, across the river.

The fifth (and best known) mission in San Antonio, the Alamo, is not part of the Park. It is located upstream from Mission Concepción, in downtown San Antonio, and is owned by the State of Texas. The Alamo was operated by the Daughters of the Republic of Texas until July 2015, when custodianship was turned over to the Texas General Land Office.

On July 5, 2015, the San Antonio Missions National Historical Park, along with the Alamo Mission in San Antonio, was designated a UNESCO World Heritage site.

In 2019, the United States Mint released a commemorative quarter as part of the America the Beautiful series honoring the park.