Nesso (Comasco: Ness [ˈnɛs]) is a comune (municipality) in the Province of Como in the Italian region Lombardy, located about 50 kilometres (31 mi) north of Milan and about 13 kilometres (8 mi) northeast of Como. As of 31 December 2004, it had a population of 1,294 and an area of 15.0 km².

Its toponym is Celtic and means "mooring".

Nesso borders the following municipalities: Argegno, Brienno, Caglio, Faggeto Lario, Laglio, Lezzeno, Pognana Lario, Sormano, Veleso, Zelbio.