Mexcaltitán de Uribe, also known simply as Mexcaltitán, is a small man-made island-city in the municipality of Santiago Ixcuintla in the Mexican state of Nayarit. Its name derives from two Náhuatl words, mexcalli ("cooked maguey, cooked agave") and suffix -titlan ("among, around; under"). Some historians have raised the possibility that it was the Aztlan of the Aztecs, their home city and birthplace from where they set out on their pilgrimage in 1091 that led them to the founding of Tenochtitlan.

This island is now being promoted as a tourist attraction. It was designated a "Pueblo Mágico" by the federal government in 2001, and, after losing the status for several years, was reinstated in the program in 2020. It is accessible by boat from La Batanga, which is the dock area located some 40 kilometers from Santiago Ixcuintla. It is known as "The Mexican Venice" (La Venecia Mexicana).

The principal tourist attraction of the island consists of its colorful houses with traditional water resistant roofs. During the rainy season it is necessary to travel by boat due to flooding in the streets.