Madeira ( mə-DEER-ə or mə-DAIR-ə; European Portuguese: [mɐˈðɐjɾɐ]), officially the Autonomous Region of Madeira (Portuguese: Região Autónoma da Madeira), is an autonomous region of Portugal. It is an archipelago situated in the North Atlantic Ocean, in the region of Macaronesia, just under 400 kilometres (250 mi) north of the Canary Islands, Spain, 520 kilometres (320 mi) west of the Morocco and 805 kilometres (500 mi) southwest of mainland Portugal. Madeira sits on the African Tectonic Plate, but is culturally, politically and ethnically associated with Europe, with its population predominantly descended from Portuguese settlers. Its population was 251,060 in 2021. The capital of Madeira is Funchal, on the main island's south coast.

The archipelago includes the islands of Madeira, Porto Santo, and the Desertas, administered together with the separate archipelago of the Savage Islands. Roughly half of the population lives in Funchal. The region has political and administrative autonomy through the Administrative Political Statute of the Autonomous Region of Madeira provided for in the Portuguese Constitution. The region is an integral part of the European Union as an outermost region. Madeira generally has a mild/moderate subtropical climate with mediterranean summer droughts and winter rain. Many microclimates are found at different elevations.

Madeira, uninhabited at the time, was claimed by Portuguese sailors in the service of Prince Henry the Navigator in 1419 and settled after 1420. The archipelago is the first territorial discovery of the exploratory period of the Age of Discovery.

Madeira is a year-round resort, particularly for Portuguese, but also British (148,000 visits in 2021), and Germans (113,000). It is by far the most populous and densely populated Portuguese island. The region is noted for its Madeira wine, flora, and fauna, with its pre-historic laurel forest, classified as a UNESCO World Heritage Site. The destination is certified by EarthCheck. The main harbour in Funchal has long been the leading Portuguese port in cruise ship dockings, an important stopover for Atlantic passenger cruises between Europe, the Caribbean and North Africa. In addition, the International Business Centre of Madeira, also known as the Madeira Free Trade Zone, was established in the 1980s. It includes (mainly tax-related) incentives.