The Friedrichstraße (German pronunciation: [ˈfʁiːdʁɪçˌʃtʁaːsə] ) (lit. Frederick Street) is a major culture and shopping street in central Berlin, forming the core of the Friedrichstadt neighborhood and giving the name to Berlin Friedrichstraße station. It runs from the northern part of the old Mitte district (north of which it is called Chausseestraße) to the Hallesches Tor in the district of Kreuzberg.

This downtown area is known for its expensive real estate market and the campus of the Hertie School of Governance. Due to its north-southerly direction, it forms important junctions with the east-western axes, most notably with Leipziger Straße and Unter den Linden. The U6 U-Bahn line runs underneath. During the Cold War it was bisected by the Berlin Wall and was the location of Checkpoint Charlie.