The Church of St. Vincent Ferrer is a Catholic parish on the Upper East Side of Manhattan, New York City. It was built in 1918 by the Dominicans; the attached priory serves as the headquarters of the Eastern United States Province of the order. Its architecture has some unusual features: above the front entrance is one of the few statues of the Crucifixion on the exterior of an American Catholic church; and inside, the Stations of the Cross depict Christ with oil paintings instead of statuary or carvings. It has two Schantz pipe organs. The church building, at the corner of Lexington Avenue and East 66th Street in the Lenox Hill section of the Upper East Side, has been called "one of New York's greatest architectural adornments."

The church is under the patronage of Saint Vincent Ferrer, a Dominican preacher from Valencia, Spain. It was made a New York City designated landmark in 1967. Seventeen years later, in 1984, the church and priory, designed in 1881 by William Schickel, were listed on the National Register of Historic Places.

St. Vincent Ferrer High School for girls is on its grounds and is administered by resident Dominican Sisters. Members also work in charitable efforts like local shelters and food pantries. They are also involved in interfaith lobbying for affordable housing in Manhattan.