The Mano del Desierto is a large-scale sculpture of a hand located in the Atacama Desert in Chile, about 60 km to the south and east of the city of Antofagasta, on the Panamerican Highway. The nearest point of reference is the "Ciudad Empresarial La Negra" (La Negra Business City). It lies between the 1309 and 1310 km marker points on the highway.