Sesriem is a small settlement in the Namib Desert, in the Hardap Region of Namibia, close to the southern end of the Naukluft Mountains. It is especially known because the "Sesriem gate" is the main access point to the Namib-Naukluft National Park for visitors entering the park to visit the nearby tourist attraction of Sossusvlei. As many "settlements" in the Namib, Sesriem is essentially a filling station with basic services such as public telephones and a couple of small kiosks where travellers can get general supplies such as food and water. In the surroundings of Sesriem there are several accommodation establishments, such as a few lodges (e.g., "Le Mirage Desert" and the "Sossusvlei Lodge") and 24 campsites.

At the Sesriem gate, hot air balloons depart in the early morning, providing scenic flights over the Sossusvlei dunes.