The Rafael Uribe Uribe Palace of Culture is a public building in Medellín, that houses cultural programs related to the Department of Antioquia, such as concerts, conferences, and art exhibitions. Belgian architect Agustín Goovaerts designed the building in a Gothic Revival style. The palace was named after Rafael Uribe Uribe, a General for the Colombian Liberal Party.

The Palace of Culture has been designated a national monument of Colombia and is freely open to the public. It houses the Institute of Culture and Heritage of Antioquia. Visitors have access to the historical and photographical archive, music and sound archive, café, library, documentation center, permanent art gallery, and “Rafael Uribe Uribe” Museum room. The large dome located in the building is also used as an auditorium and a projection room, and can be used to watch movies.