The Palouse ( pə-LOOSS) is a distinct geographic region of the northwestern United States, encompassing parts of north central Idaho, southeastern Washington, and, by some definitions, parts of northeast Oregon. It is a major agricultural area, primarily producing wheat and legumes. Situated about 160 miles (260 km) north of the Oregon Trail, the region experienced rapid growth in the late 19th century.

The Palouse is home to two land-grant universities: the University of Idaho in Moscow and Washington State University in Pullman. Just eight miles (13 km) apart, both schools opened in the early 1890s.