The first documentary testimony about the village dates from 1283 in a document about the taxes paid by the inhabitants of 7 villages and so it is believed to have been founded sometime between 1224 and 1283 by Transylvanian Saxons. The village settlement quickly developed into an important market town and by 1510 Biertan supported a population of about 5,000 people. Between 1468 and the 16th century a small fortified church (German: Kirchenburg/Wehrkirche) was constructed and developed. After the medieval period, the settlement declined in importance with the rise of neighbouring Sighișoara (German: Schäßburg), Sibiu (German: Hermannstadt), and Mediaș (German: Mediasch).

In the Romanian census of 1930, Biertan had 2,331 inhabitants, of whom 1,228 were Transylvanian Saxons. During World War II many men were conscripted into the Romanian army and later on forcefully drafted in the Waffen-SS. After the war, many Transylvanian Saxons were deported from the region to labour camps in the former Soviet Union (USSR). During communism, many left for West Germany. Following the collapse of communism in 1990, many more left for Germany.

Today the whole commune has a population of about 2,500 and the village of Biertan alone has about 1,600 people. It is one of the most visited villages in Transylvania, being the historically important place of the annual reunion of the Transylvanian Saxons, many of whom now live in Germany.